Synthesis of milbemycins beta9 and beta10 from milbemycins A3 and A4 and their biological activities

Takahiro Tsukiyama; Ayako Kinoshita; Reiji Ichinose; Kazuo Sato

doi:10.1271/bbb.66.1407

Synthesis of milbemycins beta9 and beta10 from milbemycins A3 and A4 and their biological activities

Biosci Biotechnol Biochem. 2002 Jun;66(6):1407-11. doi: 10.1271/bbb.66.1407.

Authors

Takahiro Tsukiyama¹, Ayako Kinoshita, Reiji Ichinose, Kazuo Sato

Affiliation

¹ Agroscience Research Laboratories, Sankyo Co. Ltd., Shiga, Japan. tukiya@yasu.sankyo.co.jp

PMID: 12162570
DOI: 10.1271/bbb.66.1407

Abstract

Chemical derivation methods were used to prepare milbemycins beta9 and beta10 from milbemycins A3 and A4. Their acaricidal activities were also assessed against the organophosphorus-sensitive two-spotted spider mite (Tetranychus urticae) on primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.

MeSH terms

Animals
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Fabaceae / parasitology
Macrolides / chemical synthesis*
Macrolides / chemistry
Macrolides / pharmacology*
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Leaves / parasitology
Tetranychidae / drug effects

Substances

Anti-Bacterial Agents
Macrolides
milbemycin beta10
milbemycin beta9
moxidectin