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Neurosci Lett. 2002 Aug 23;329(1):5-8.

Skin graft on the surgically induced spinal open neural tube defects does not induce lipomatous malformation but enhances re-closure to the normal state in chick embryos.

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Division of Pediatric Neurosurgery and Laboratory for Fetal Medicine Research, Clinical Research Institute, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea.


To determine the effect of skin allograft on open neural tube defects (ONTDs), the neural tube was incised open using Hamburger and Hamilton stage 18 or 19 chick embryos for a length of six somites. Embryos were divided into two groups: graft and control (with and without skin allograft). On postoperative day 5, closure of ONTDs was more frequent in the graft group than in the control group (9/15 versus 0/15), and healing was nearly complete. However, typical lipomatous features were not observed. These results suggest that simple mechanical attachment of skin allograft on ONTDs does not lead to lipomatous malformation in chick embryos. On the other hand, our results support a potential role of skin allograft in the management of prenatal spinal ONTDs.

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