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Bioorg Med Chem Lett. 2002 Sep 2;12(17):2483-6.

Hepatobiliary excretion of dipyrrinone sulfonates in Mrp2-deficient (TR(-)) rats.

Author information

1
Division of Gastroenterology, S-357, Box 0538, University of California, San Francisco, CA 94143-0538, USA. tonymcd@itsa.ucsf.edu

Abstract

The biliary excretion of the sodium salts of 8-(2-ethanesulfonic acid)-3-ethyl-2,7,9-trimethyl-1,10-dihydro-11H-dipyrrin-1-one (xanthosulfonic acid) and a fluorescent analogue (8-desethyl-N,N'-carbonyl-kryptopyrromethenone-8-sulfonic acid) was compared in Mrp2-deficient (TR(-)) and normal rats. Both organic anions were excreted rapidly in bile in Mrp2-deficient rats, but the biliary excretion of the fluorescent sulfonate was impaired relative to normal controls. The rat clearly has efficient Mrp2-independent mechanisms for biliary efflux of these anions that are not used by bilirubin or its mono- and diglucuronides.

PMID:
12161163
DOI:
10.1016/s0960-894x(02)00395-5
[Indexed for MEDLINE]

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