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Neuron. 2002 Jul 18;35(2):219-22.

Animal models of PD: pieces of the same puzzle?

Author information

1
The Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. tdawson@jhmi.edu

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder with no known cure. The etiology of PD is likely due, in part, to combinations of genetic susceptibilities and environmental factors. In rare familial cases, PD is due to genetic mutations. A number of new genetic and toxin models of PD and advances in older models are yielding important new information about the pathogenesis of PD. This has prompted us to critically review the current animal models for PD and discuss how these models may yield fresh insights into the pathogenesis of PD, as well as new therapeutic opportunities.

PMID:
12160740
DOI:
10.1016/s0896-6273(02)00780-8
[Indexed for MEDLINE]

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