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J Med Dent Sci. 2001 Mar;48(1):1-6.

Wiskott-Aldrich syndrome (role of WASP).

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1
Department of Pediatrics, School of Medicine, Tokyo Medical and Dental University, Japan. snonoyama.ped@tmd.ac.jp

Abstract

Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by thrombocytopenia, eczema and immunodeficiency. WASP, the gene responsible for WAS, has been identified by positional cloning, contains a PH domain, a GBD domain, a proline rich region, and a verprolin/cofilin homology domain. Subsequent studies suggest that WASP is involved in signal transduction and in the regulation of the cytoskeleton.

PMID:
12160237
[Indexed for MEDLINE]
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