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Nat Rev Mol Cell Biol. 2002 Aug;3(8):586-99.

ERM proteins and merlin: integrators at the cell cortex.

Author information

1
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. apb5@cornell.edu

Abstract

A fundamental property of many plasma-membrane proteins is their association with the underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and other plasma-membrane processes, including endocytosis and exocytosis. The ezrin-radixin-moesin (ERM) proteins are crucial components that provide a regulated linkage between membrane proteins and the cortical cytoskeleton, and also participate in signal-transduction pathways. The closely related tumour suppressor merlin shares many properties with ERM proteins, yet also provides a distinct and essential function.

PMID:
12154370
DOI:
10.1038/nrm882
[Indexed for MEDLINE]

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