Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Mol Cell Biol. 2002 Aug;3(8):566-74.

Plasticity and reprogramming of differentiated cells in amphibian regeneration.

Author information

1
Department of Biochemistry & Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK. j.brockes@ucl.ac.uk

Abstract

Adult urodele amphibians, such as the newt, can regenerate their limbs and various other structures. This is the result of the plasticity and reprogramming of residual differentiated cells, rather than the existence of a 'reserve-cell' mechanism. The recent demonstrations of plasticity in mouse myotubes should facilitate comparative studies of the pathways that underlie the regenerative response, as well as proposing new approaches to promote mammalian regeneration.

PMID:
12154368
DOI:
10.1038/nrm881
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center