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Nat Rev Cancer. 2002 Aug;2(8):627-33. doi: 10.1038/nrc862.

Telomerase beyond telomeres.

Author information

1
Department of Immunology and Oncology, National Centre of Biotechnology, E-28049 Madrid, Spain. mblasco@cnb.uam.es

Abstract

The role of telomerase in actively proliferating cells is assumed to be restricted to maintaining of telomeres above a minimum-length threshold, thereby preventing telomere exhaustion and chromosomal instability. However, forced telomerase expression in cells and mice with normal-length telomeres has shown that telomerase promotes growth and survival in a manner that is uncoupled from net telomere lengthening. These findings imply that telomerase might have a fundamental role in tumour growth and survival, even at stages when telomeres are sufficiently long.

PMID:
12154355
DOI:
10.1038/nrc862
[Indexed for MEDLINE]

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