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Nat Rev Cancer. 2002 Aug;2(8):573-83.

Lymphangiogenesis and cancer metastasis.

Author information

1
Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia.

Abstract

Lymphatic vessels are important for the spread of solid tumours, but the mechanisms that underlie lymphatic spread and the role of lymphangiogenesis (the growth of lymphatics) in tumour metastasis has been less clear. This article reviews recent experimental and clinico-pathological data indicating that growth factors that stimulate lymphangiogenesis in tumours are associated with an enhanced metastatic process.

PMID:
12154350
DOI:
10.1038/nrc863
[Indexed for MEDLINE]

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