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Cell. 2002 Jul 12;110(1):1-4.

Dancing with the host; flow-dependent bacterial adhesion.

Author information

1
Howard Hughes Medical Institute, Boston, MA 02111, USA. ralph.isberg@tufts.edu

Abstract

Most bacteria that colonize eukaryotes must bind directly to host cells to establish a replicative niche. In enteric bacteria, adhesion to host cells is often promoted by a lectin found on surface-localized pili. Some pili promote efficient adhesion only when they are subjected to shear stress, as found during the flow of blood over endothelium or mucous over the surface of the epithelium.

PMID:
12150990
DOI:
10.1016/s0092-8674(02)00821-8
[Indexed for MEDLINE]

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