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Mol Cell. 2002 Jul;10(1):7-8.

Smad about E2F. TGFbeta repressionof c-Myc via a Smad3/E2F/p107 complex.

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Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA.


Signaling by TGFbeta regulates the expression of hundreds of genes. The rapid repression of c-Myc stands out because of its roles in growth control and cancer. Recent work shows that c-Myc repression by TGFbeta is mediated by the nuclear translocation of a novel, preformed complex composed of Smad3, E2F4 or E2F5, and the Rb-related factor p107.

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