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Mol Cell. 2002 Jul;10(1):2-4.

The two faces of BRCA2, a FANCtastic discovery.

Author information

1
Howard Hughes Medical Institute, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, One Baylor Plaza, Houston, TX 77030, USA.

Abstract

The molecular defects responsible for the cancer predisposition syndrome Fanconi's Anemia (FA) have been elusive. A recent study reports that the FANC-B and -D1 subgroups result from hypomorphic mutations in BRCA2. Given that BRCA2 protein participates in homologous recombination, this finding connects at least a subset of the FA phenotypes to defective DNA repair.

PMID:
12150898
DOI:
10.1016/s1097-2765(02)00580-4
[Indexed for MEDLINE]
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