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Immunity. 2002 Jul;17(1):51-62.

Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program.

Author information

1
Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Blimp-1, a transcriptional repressor, drives the terminal differentiation of B cells to plasma cells. Using DNA microarrays, we found that introduction of Blimp-1 into B cells blocked expression of a remarkably large set of genes, while a much smaller number was induced. Blimp-1 initiated this cascade of gene expression changes by directly repressing genes encoding several transcription factors, including Spi-B and Id3, that regulate signaling by the B cell receptor. Blimp-1 also inhibited immunoglobulin class switching by blocking expression of AID, Ku70, Ku86, DNA-PKcs, and STAT6. These findings suggest that Blimp-1 promotes plasmacytic differentiation by extinguishing gene expression important for B cell receptor signaling, germinal center B cell function, and proliferation while allowing expression of important plasma cell genes such as XBP-1.

PMID:
12150891
[Indexed for MEDLINE]
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