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Genet Couns. 2002;13(2):133-8.

Confirmation of a gene for multiple sclerosis (MS) to chromosome region 19q13.3.

Author information

1
Laboratory of Molecular Neurogenetics, Paris, France.

Abstract

To identify the chromosomal localizations of the multiple sclerosis (MS) genes, we conducted a genomewide linkage analysis using eighteen affected families. A MS gene is linked to markers located in the 19q13.3 region (multipoint lod-score = 2.1). Apolipoprotein E (ApoE) gene, located in this region, is an excellent candidate gene for MS because the ApoEe4 allele is acting as a severity allele in the disease.

PMID:
12150212
[Indexed for MEDLINE]

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