Format

Send to

Choose Destination
Thorax. 2002 Aug;57(8):749-50.

Profound adrenal suppression secondary to treatment with low dose inhaled steroids and itraconazole in allergic bronchopulmonary aspergillosis in cystic fibrosis.

Author information

1
Adult CF Unit Papworth Hospital, Papworth NHS Trust, Papworth Everard, Cambridge CB3 8RE, UK. jsp35@hermes.cam.ac.uk

Abstract

The case history is presented of a patient with cystic fibrosis in whom the treatment of allergic bronchopulmonary aspergillosis with itraconazole produced an initial response but was complicated by profound adrenal shutdown and impairment of inhaled steroid clearance resulting in paradoxical Cushing's syndrome. The authors conclude that, while it is laudable to attempt to reduce the steroid burden in any patient, it is imperative that due vigilance is exercised when using a combination of agents which interact. If such a combination therapy is embarked upon, regular assessment of the pituitary adrenal axis is advisable.

PMID:
12149540
PMCID:
PMC1746400
DOI:
10.1136/thorax.57.8.749
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center