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Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10370-5. Epub 2002 Jul 29.

Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy.

Author information

1
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Abstract

Voltage-dependent L-type Ca(2+) channels play important functional roles in many excitable cells. We present a three-dimensional structure of an L-type Ca(2+) channel. Electron cryomicroscopy in conjunction with single-particle processing was used to determine a 30-A resolution structure of the channel protein. The asymmetrical channel structure consists of two major regions: a heart-shaped region connected at its widest end with a handle-shaped region. A molecular model is proposed for the arrangement of this skeletal muscle L-type Ca(2+) channel structure with respect to the sarcoplasmic reticulum Ca(2+)-release channel, the physical partner of the L-type channel for signal transduction during the excitation-contraction coupling in muscle.

PMID:
12149473
PMCID:
PMC124921
DOI:
10.1073/pnas.162363499
[Indexed for MEDLINE]
Free PMC Article

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