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Lancet. 2002 Jul 27;360(9329):309-10.

Malignant transformation of a vestibular schwannoma after gamma knife radiosurgery.

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Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan.


Stereotactic radiosurgery is used to treat benign tumours, but its long-term effects are not fully understood. Here we describe a vestibular schwannoma that underwent malignant transformation 6 years after gamma knife radiosurgery applied to the tumour remnant after a primary resection. Histological specimens of the original specimen did not show any atypical features. Genotyping showed a TP53 mutation in the recurrent tumour, which did not exist in the original tumour. Our results suggest that radiosurgery induced the malignant transformation, and we propose a cautious application of this treatment for benign tumours.

[Indexed for MEDLINE]

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