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Biochim Biophys Acta. 2002 Jul 29;1598(1-2):140-6.

The DpsA-homologue of the archaeon Halobacterium salinarum is a ferritin.

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Isotopenlabor TNF, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, Lübeck, Germany.


An iron-rich protein, DpsA(Hsal), was isolated from the archaeon Halobacterium salinarum sharing a sequence identity of 35% with the starvation-induced DNA-binding protein, DpsA, of Synechecoccus sp. PCC7942. It consists of 20-kDa subunits forming a dodecameric structure. The protein exhibits a ferric iron loading of up to 100 Fe ions per mole of holoprotein. CD spectra and secondary structure calculations are consistent with an alpha-helical contribution of 60%. The UV/VIS spectrum provides no evidence for the presence of heme groups. This protein exhibits features of a non-heme type bacterial ferritin (Ftn) although it shares only little sequence homology with Ftn. Molecular modelling disclosed a high structural similarity to E. coli Dps.

[Indexed for MEDLINE]

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