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Med Mycol. 2002 Jun;40(3):259-62.

fos-1, a putative histidine kinase as a virulence factor for systemic aspergillosis.

Author information

1
California Institute for Medical Research, San Jose 95128, USA. clemons@cimr.org

Abstract

In fungi, two-component histidine kinases have various functions including regulation of osmosensitivity, and of cell-wall assembly. Furthermore, one of these proteins, cos-1, has been shown to be important for virulence of Candida albicans. Recently, a putative histidine kinase, fos-1, has been isolated and partially characterized from Aspergillus fumigatus. Here we compare the virulence of a fos-1 deletion strain with that of the parental wild-type strain in a murine model of systemic aspergillosis. Our results show that the fos-1 deletion strain has significantly reduced virulence as compared with the parental wild-type strain. Thus, we propose that the fos-1 two-component histidine kinase is a virulence factor of A. fumigatus.

PMID:
12146755
DOI:
10.1080/mmy.40.3.259.262
[Indexed for MEDLINE]

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