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Nat Genet. 2002 Sep;32(1):107-8. Epub 2002 Jul 29.

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice.

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1
Mirus Corporation, 505 South Rosa Road, Madison, Wisconsin 53719, USA. davel@genetransfer.com

Abstract

It has recently been shown that RNA interference can be induced in cultured mammalian cells by delivery of short interfering RNAs (siRNAs). Here we describe a method for efficient in vivo delivery of siRNAs to organs of postnatal mice and demonstrate effective and specific inhibition of transgene expression in a variety of organs.

PMID:
12145662
DOI:
10.1038/ng944
[Indexed for MEDLINE]
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