Send to

Choose Destination
Planta Med. 2002 Jul;68(7):621-5.

Mururins A-C, three new lignoids from Brosimum acutifolium and their protein kinase inhibitory activity.

Author information

Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, Yokohama, Japan.


Two new flavonolignans, mururins A and B ( 1 and 2), and a new lignan, mururin C ( 3), were isolated from the bark of Brosimum acutifolium Huber together with three known lignans. Their structures were elucidated by spectroscopic means and chemical modifications. They were tested for protein kinase A (PKA) and protein kinase C (PKC) inhibitory activity. Mururin A showed 3 % and 63 % inhibition to PKA and PKC, respectively, at 20 microM. Mururin B showed 58 % and 38 % inhibition, respectively. Mururin C did not have significant activity.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Georg Thieme Verlag Stuttgart, New York
Loading ...
Support Center