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Science. 2002 Jul 26;297(5581):620-3.

Identification of Bphs, an autoimmune disease locus, as histamine receptor H1.

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  • 1Laboratory Animal Center, Institute of Genetics, Chinese Academy of Sciences, Beijing, China 100101.

Abstract

Bphs controls Bordetella pertussis toxin (PTX)-induced vasoactive amine sensitization elicited by histamine (VAASH) and has an established role in autoimmunity. We report that congenic mapping links Bphs to the histamine H1 receptor gene (Hrh1/H1R) and that H1R differs at three amino acid residues in VAASH-susceptible and -resistant mice. Hrh1-/- mice are protected from VAASH, which can be restored by genetic complementation with a susceptible Bphs/Hrh1 allele, and experimental allergic encephalomyelitis and autoimmune orchitis due to immune deviation. Thus, natural alleles of Hrh1 control both the autoimmune T cell and vascular responses regulated by histamine after PTX sensitization.

PMID:
12142541
DOI:
10.1126/science.1072810
[PubMed - indexed for MEDLINE]
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