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Annu Rev Genomics Hum Genet. 2002;3:153-78. Epub 2002 Apr 15.

Developmental genomic approaches in model organisms.

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Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA.


Functional genomics technologies can help decipher how information encoded in the genome is translated into morphology, physiology, and behavior during the development of complex organisms. A number of researchers have begun to apply DNA microarrays and other functional genomics approaches to study development. Here we review recent studies that take the first steps toward relating genome-wide information to developmental events, we discuss recent genomics approaches taken in animal model systems used to study human disease, and we outline methods that may be useful for constructing genome-wide maps of developmental processes.

[Indexed for MEDLINE]

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