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Trends Genet. 2002 Aug;18(8):387-9.

Connecting the DOTs: covalent histone modifications and the formation of silent chromatin.


Histone methylation has emerged as a significant regulator of chromatin structure and function. Two different classes of histone methyltransferase (HMT) have been described, which target either lysine or arginine residues in the histone N-terminal tails. A flurry of recent papers now describe a third class of HMT that affects chromatin silencing indirectly, not by methylation of histone tails, but instead by targeting a conserved lysine residue in the core domain of the nucleosome.

[Indexed for MEDLINE]

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