Format

Send to

Choose Destination
See comment in PubMed Commons below
Brief Bioinform. 2002 Jun;3(2):146-53.

Genetic association studies: design, analysis and interpretation.

Author information

1
Division of Medical and Molecular Genetics, Guy's Hospital, London, UK. cathryn.lewis@kcl.ac.uk

Abstract

This paper provides a review of the design and analysis of genetic association studies. In case control studies, the different contingency tables and their relationships to the underlying genetic model are defined. Population stratification is discussed, with suggested methods to identify and correct for the effect. The transmission disequilibrium test is provided as an alternative family-based test, which is robust to population stratification. The relative benefits of each analysis are summarised.

PMID:
12139434
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center