The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies

News Physiol Sci. 2002 Aug:17:131-7. doi: 10.1152/nips.01388.2002.

Abstract

Hypoxic pulmonary vasoconstriction matches perfusion to ventilation and optimizes systemic oxygenation. Alterations in PO(2) are sensed by a vascular redox O(2) sensor in the pulmonary artery smooth muscle cell, probably within the mitochondria. This creates a signal that modulates redox-sensitive K(+) channels, thereby controlling membrane potential, Ca(2+) entry, and tone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chemoreceptor Cells / physiology
  • Humans
  • Hypoxia / metabolism*
  • Hypoxia / physiopathology
  • Oxidation-Reduction
  • Oxygen / metabolism*
  • Potassium Channels / metabolism*
  • Pulmonary Circulation / physiology*
  • Vasoconstriction / physiology*

Substances

  • Potassium Channels
  • Oxygen