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Int J Antimicrob Agents. 2002 Jun;19(6):461-5.

Vaccines for Proteus mirabilis in urinary tract infection.

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Department of Microbiology and Immunology, University of Maryland School of Medicine, 655 W. Baltimore Street, Room 13-009, Baltimore, MD 21201, USA.


Proteus mirabilis is a documented cause of urinary tract infection (UTI) in the complicated urinary tract. Urease-mediated urea hydrolysis is responsible for both virulence of the organism and the ability to cause urolithiasis. A urease-negative mutant of P. mirabilis is unable to initiate stone formation and colonizes the kidney at a significantly lower rate. The considerable pathology caused by P. mirabilis warrants the development of a vaccine. We have initiated the advancement of vaccine studies and have determined that the MR/P fimbria, a surface adhesin of P. mirabilis, is a promising vaccine candidate. Successful vaccination would be expected both to prevent colonization by P. mirabilis and urolithiasis.

[Indexed for MEDLINE]

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