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Tissue Antigens. 2002 Apr;59(4):308-10.

Characterization of a novel MICA allele, MICA*047.

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Department of Internal Medicine, UT South-western Medical Center, Dallas 75390-8886, USA.


We report the identification of a novel MICA allele, MICA*047. It was initially detected because of an unusual hybridization pattern with sequence-specific oligonucleotides (SSOP) in a normal subject of Caucasian origin. Cloning and sequencing of both strands, and comparison of the sequence with previously defined MICA alleles, revealed that the new allele is similar to MICA*041 except for one nucleotide substitution at position 811 (C-->G). It appears that this new allele could have been generated by an interallelic sequence exchange between MICA*011 and MICA*0411.

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