Format

Send to

Choose Destination
J Infect Dis. 2002 Jul 15;186(2):240-5. Epub 2002 Jul 3.

Cytokine release by lipopolysaccharide-stimulated whole blood from patients with typhoid fever.

Author information

1
Centre for Molecular Microbiology and Infection, Imperial College of Science, Technology, and Medicine, London, United Kingdom. d.house@ic.ac.uk

Abstract

The ex vivo cytokine response to lipopolysaccharide (LPS) of whole blood from patients with typhoid fever was investigated. Tumor necrosis factor (TNF)-alpha release by LPS-stimulated blood was found to be lower during acute typhoid fever than after a course of antimicrobial therapy (P<or=.001). Ex vivo interleukin (IL)-1beta, but not IL-1 receptor antagonist, release was also depressed during the acute stage of typhoid fever. Low ex vivo production of TNF-alpha was associated with delayed recovery. No association was found between the TNFA-308 promoter polymorphism and LPS-induced TNF-alpha release, either during an active infection or after treatment. In acute typhoid fever, the ability of peripheral blood leukocytes to release proinflammatory cytokines in response to an inflammatory stimulus is depressed, and this may contribute to delayed recovery following antibiotic treatment.

PMID:
12134261
DOI:
10.1086/341298
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center