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J Affect Disord. 2002 Aug;70(3):323-7.

Severity of bipolarity in hospitalized manic adolescents with history of stimulant or antidepressant treatment.

Author information

1
University of Cincinnati, Department of Psychiatry, Biological Psychiatry and Psychotic and Bipolar Disorders Research Programs, PO Box 670559, 231 Bethesda Avenue, Cincinnati, OH 45267-0559, USA. csoutullo@unav.es

Abstract

BACKGROUND:

Childhood bipolarity (BP) and ADHD frequently co-occur, these children often receive stimulants.

METHOD:

We retrospectively evaluated 80 adolescents hospitalized with BP, manic or mixed, assessed severity of hospital course, and compared groups according to current/past stimulant or antidepressant treatment.

RESULTS:

Lifetime ADHD rate was 49%; 35% of patients had exposure to stimulants and 44% to antidepressants. Stimulant-exposed patients were younger than non-exposed (mean+/-S.D.=13.7+/-2 vs. 15.1+/-2 years, Z=-3.1, P=0.002). Only stimulant exposure was associated with worse hospitalization course (MANCOVA, Wilks' Lambda=0.87, F=3.4; df=70; P=0.02).

CONCLUSION:

Stimulant-exposed BP-adolescents may have more severe illness course not fully explained by ADHD comorbidity.

LIMITATIONS:

Retrospective methodology and lack of structured interviewing make it difficult to quantify exposure to stimulants and antidepressants.

PMID:
12128245
[Indexed for MEDLINE]
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