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Int J Biochem Cell Biol. 2002 Oct;34(10):1184-9.

The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals.

Author information

1
Immunology Research Laboratories and Department of Veterinary Science, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA. axa45@psu.edu

Abstract

ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. These kinases require prior activation of Lck, Zap-70 and PI3-kinase for efficient activation. They share major substrates with both Lck and Zap-70, however the pathways they regulate are unclear. Recent evidence suggests that these kinases may not activate unique pathways, but instead serve as amplifiers for the upstream kinases Lck and Zap-70. This review will discuss the evidence for this view.

PMID:
12127569
DOI:
10.1016/s1357-2725(02)00068-7
[Indexed for MEDLINE]

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