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Bioorg Med Chem Lett. 2002 Aug 19;12(16):2201-4.

Design and synthesis of novel inhibitors of gelatinase B.

Author information

1
Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720, USA.

Abstract

A new method was developed to identify nonpeptidic metalloproteinase inhibitors with novel zinc binding groups. Application of this method to matrix metalloproteinase-9 resulted in the identification of aminomethyl benzimidazole analogue 7a with an IC(50)=13 microM.

PMID:
12127537
[Indexed for MEDLINE]

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