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Bioorg Med Chem Lett. 2002 Aug 19;12(16):2197-200.

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. willoughby@merk.com

Abstract

A novel class of small molecule human granzyme B inhibitors is reported. Compound 20 has a K(i) of 7 nM against human granzyme B and blocks CTL mediated apoptosis with an IC(50) of 3 micromolar.

PMID:
12127536
DOI:
10.1016/s0960-894x(02)00363-3
[Indexed for MEDLINE]

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