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Bioorg Med Chem Lett. 2002 Aug 19;12(16):2133-6.

3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists.

Author information

1
Neurogen Corporation, 35Northeast Industrial Road, Branford, CT 06405, USA.

Abstract

The synthesis of a series of 3-aryl pyrazolo[4,3-d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring on CRF-1 receptor binding were investigated.

PMID:
12127521
DOI:
10.1016/s0960-894x(02)00358-x
[Indexed for MEDLINE]

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