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Bioorg Med Chem Lett. 2002 Aug 19;12(16):2065-8.

Biphenyl derivatives as novel dual NK(1)/NK(2)-receptor antagonists.

Author information

1
Pharma Research, Novartis Pharma AG, CH-4002, Basel, Switzerland. robert.mah@speedelgroup.com

Abstract

In a continuation of our efforts to simplify the structure of our neurokinin antagonists, a series of substituted biphenyl derivatives has been prepared. Several compounds exhibit potent affinities for both the NK(1) receptor (<10nM) and for the NK(2) receptor (<50 nM). Details on the design, synthesis, biological activities, SAR and conformational analysis of this new class of dual NK(1)/NK(2) receptor antagonists are presented.

PMID:
12127505
DOI:
10.1016/s0960-894x(02)00382-7
[Indexed for MEDLINE]

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