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Semin Cell Dev Biol. 2002 Apr;13(2):99-106.

Expression of SNAP-25 during mammalian retinal development: thinking outside the synapse.

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Department of Biomedical Sciences and Neuroscience Program, Iowa State University, Ames, IA 50011, USA.


The SNARE complex is the core machinery required for vesicle fusion events. Numerous structural, functional, and genetic studies have led to a better understanding of mechanisms that regulate vesicle fusion events during neural development. Studies using the mammalian retina as a model system have increased our understanding of the dynamic patterns of expression of SNARE proteins. In particular, the SNARE complex protein SNAP-25 is expressed in a dynamic fashion during the development of cholinergic amacrine cells in a number of mammalian species. SNAP-25 is also likely to play a crucial role during the development of vertebrate photoreceptors. The integration of comparative studies examining SNARE proteins, such as SNAP-25, provides a powerful approach for the study of CNS development.

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