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Brain Res Bull. 2002 Jun;58(2):213-8.

Comparisons between C57BL/6J and A/J mice in motor activity and coordination, hole-poking, and spatial learning.

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Laboratoire de médecine moléculaire and Service de neurologie, Centre de recherche, Hôtel-Dieu du Centre hospitalier de l'Université de Montréal, Qué., Montréal, Canada.


The C57BL/6J (B6) inbred mouse strain was compared to the A/J inbred strain for motor activity in an open-field, exploration of a hole-board, motor coordination in the coat-hanger test, and spatial learning in the Morris water maze. B6 mice displayed a higher number of segment crossings in the open-field and of hole-poking responses than A/J mice. The performance of B6 mice was superior to that of A/J mice not only in the submerged but also in the visible platform version of the Morris water maze. By contrast to their hypoactivity, the A/J strain had shorter movement times in the coat-hanger test, indicating faster motor speed, although the groups did not differ in latencies before falling. These results indicate that recombinant inbred or congenic strains derived from B6 and A/J mice offer considerable potential for discerning the genetic basis of several behavioral phenotypes.

[Indexed for MEDLINE]

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