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Mol Membr Biol. 2002 Apr-Jun;19(2):103-12.

Molecular complexity of vertebrate tight junctions (Review).

Author information

1
Department of Molecular Biology, University of Geneva, Switzerland.

Abstract

Separation of distinct body, organ and tissue compartments, and maintenance of epithelial cell polarity require tight junctions (TJ)-cell-cell junctions located in the apicolateral regions of epithelial and endothelial cells. Studies on the protein components of vertebrate TJ have revealed an intricate network of membrane, sub-membrane, cytoskeletal, and signalling molecules. How these molecules functionally interact to provide TJ with their functions, and what roles these molecules play in control of cell growth and differentiation is a fundamental problem in cell biology.

PMID:
12126228
DOI:
10.1080/09687680210129236
[Indexed for MEDLINE]

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