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Cell Biochem Funct. 2002 Sep;20(3):227-32.

Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D(3).

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  • 1Department of Biochemistry and Molecular Biology, Faculty of Medicine, Complutense University of Madrid, Spain.

Abstract

Treatment with 10(-8) M 1,25-dihydroxyvitamin D(3) for 24 h causes transcriptional activation of the human insulin receptor gene in U-937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinositol 3-kinase inhibitor, causes a greater inhibition of insulin-stimulated glucose oxidation in 1,25-dihydroxyvitamin D(3)-treated cells than in untreated cells. This suggests a stimulation of phosphatidylinositol 3-kinase activity by 1,25-dihydroxyvitamin D(3), which could mediate, at least in part, the potentiation of the insulin response.

PMID:
12125099
DOI:
10.1002/cbf.951
[PubMed - indexed for MEDLINE]
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