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Neuron. 2002 Jul 3;35(1):13-6.

Signaling the pathway to regeneration.

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  • 1Neuroscience Center, University of North Carolina, Chapel Hill 27599, USA.


Robust axon regeneration occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. Two independent studies now report that upregulation of cAMP is a component of the PNS regeneration program that can be exploited to enhance axon regeneration through the normally inhibitory CNS environment.

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