Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuron. 2002 Jul 3;35(1):9-12.

Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

Author information

1
Department of Pharmacology, University of Washington, Seattle 98195, USA. mucho@u.washington.edu

Abstract

The most conspicuous feature of many neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's disease, is the occurrence of protein aggregates in ordered fibrillar structures known as amyloid found inside and outside of brain cells. The appearance of aggregates in diseased brains implies an underlying incapacity in the cellular machinery of molecular chaperones that normally functions to prevent the accumulation of misfolded proteins. Here we review recent studies that have revealed a critical role for molecular chaperones in several neurodegenerative disorders.

PMID:
12123602
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center