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Curr Biol. 2002 Jun 25;12(12):R429-31.

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

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1
Department of Cell Biology, Harvard Medical School, 240 Longwood Ave/ C-1, 502, Boston, Massachusetts 02115, USA. orion_weiner@hms.harvard.edu

Abstract

P-Rex1, a novel Rac activator, has been identified in the first biochemical purification of a guanine nucleotide exchange factor for GTPases of the Rho family. P-Rex1 is synergistically activated by PIP(3) and Gbetagamma and may act as a coincidence detector for these signaling molecules.

PMID:
12123595
PMCID:
PMC2819105
[Indexed for MEDLINE]
Free PMC Article
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