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Antimicrob Agents Chemother. 2002 Aug;46(8):2700-3.

Biguanide-atovaquone synergy against Plasmodium falciparum in vitro.

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1
Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool L35QA, United Kingdom.

Abstract

The synergistic potential of a range of biguanides, their triazine metabolites, tetracyclines, and pyrimethamine in combination with atovaquone has been assessed. All five biguanides tested interacted synergistically with atovaquone against Plasmodium falciparum in vitro. All of the other compounds tested were either additive or antagonistic.

PMID:
12121961
PMCID:
PMC127339
[Indexed for MEDLINE]
Free PMC Article
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