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Antimicrob Agents Chemother. 2002 Aug;46(8):2687-91.

Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor.

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1
HIV Research Laboratory, Ottawa Health Research Institute, Ottawa, Ontario, Canada K1H 8L6.

Abstract

Inhibition of human immunodeficiency virus type 1 reverse transcriptase (RT) by both nucleoside and nonnucleoside RT inhibitors profoundly inhibits virus replication. Nucleoside RT inhibitors are known to be toxic, but there is little information regarding the toxicities of nonnucleoside RT inhibitors (NNRTI). We demonstrate that efavirenz (an NNRTI) induces caspase- and mitochondrion-dependent apoptosis of Jurkat T cells and human peripheral blood mononuclear cells. The clinical relevance of these observations is not yet clear.

PMID:
12121958
PMCID:
PMC127389
[Indexed for MEDLINE]
Free PMC Article
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