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Immunity. 2002 Jun;16(6):755-8.

Further checkpoints in Th1 development.

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Allergy and Clinical Immunology and Leukocyte Biology, Faculty of Medicine, Imperial College, SW7 2AK, London, United Kingdom.


Tight control of Th1 immunity is essential to prevent immunopathology. Central to control of the IFN-gamma gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is dominant in directing Th1 development, while synergizing with IL-18 for IFNgamma production from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function.

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