Format

Send to

Choose Destination
See comment in PubMed Commons below
Immunity. 2002 Jun;16(6):755-8.

Further checkpoints in Th1 development.

Author information

  • 1Allergy and Clinical Immunology and Leukocyte Biology, Faculty of Medicine, Imperial College, SW7 2AK, London, United Kingdom.

Abstract

Tight control of Th1 immunity is essential to prevent immunopathology. Central to control of the IFN-gamma gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is dominant in directing Th1 development, while synergizing with IL-18 for IFNgamma production from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function.

PMID:
12121657
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center