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Nat Rev Drug Discov. 2002 Feb;1(2):153-61.

Metabonomics: a platform for studying drug toxicity and gene function.

Author information

1
Biological Chemistry Section, Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AZ, UK. j.nicholson@ic.ac.uk

Abstract

The later that a molecule or molecular class is lost from the drug development pipeline, the higher the financial cost. Minimizing attrition is therefore one of the most important aims of a pharmaceutical discovery programme. Novel technologies that increase the probability of making the right choice early save resources, and promote safety, efficacy and profitability. Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery-and-development process.

PMID:
12120097
DOI:
10.1038/nrd728
[Indexed for MEDLINE]
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