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Nat Rev Drug Discov. 2002 Jan;1(1):65-75.

Targeting glycosylation as a therapeutic approach.

Author information

1
Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. rad@bioch.ox.ac.uk

Abstract

Increased understanding of the role of protein- and lipid-linked carbohydrates in a wide range of biological processes has led to interest in drugs that target the enzymes involved in glycosylation. But given the importance of carbohydrates in fundamental cellular processes such as protein folding, therapeutic strategies that modulate, rather than ablate, the activity of enzymes involved in glycosylation are likely to be a necessity. Two such approaches that use imino sugars to affect glycosylation enzymes now show considerable promise in the treatment of viral infections, such as hepatitis B, and glucosphingolipid storage disorders, such as Gaucher disease.

PMID:
12119611
DOI:
10.1038/nrd708
[Indexed for MEDLINE]
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