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Trends Pharmacol Sci. 2002 Jul;23(7):299-302.

Cerebral cystine uptake: a tale of two transporters.

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1
Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. Gethin.McBean@ucd.ie

Abstract

Transport of cystine across the cell membrane is essential for synthesis of the major cellular antioxidant glutathione. Cystine uptake in the brain occurs by both the Na(+)-independent x(c)(-) cystine-glutamate exchanger and the X(AG)(-) family of high-affinity, Na(+)-dependent glutamate transporters. New evidence concerning the role of cystine transport in the defence against oxidative stress is described.

PMID:
12119142
[Indexed for MEDLINE]
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