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Nat Neurosci. 2002 Aug;5(8):721-2.

Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.

Author information

1
Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Brooklyn, New York 11203, USA.

Abstract

Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of delta-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased.

PMID:
12118257
PMCID:
PMC2887346
DOI:
10.1038/nn888
[Indexed for MEDLINE]
Free PMC Article

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